988
Index
Deficiency of vitamin B
12
, 333
Deficient or excessive signal pertusis, 604
Deficient signal, 604
Degenerative syndromes, 478
Degradation of DNA, 530
Dehydration of 2-phosphoglycerate to
phosphoenolpyruvate, 232
Déhydroépiandrostérone (DHEA), 705,
750, 757
Dehydrogenation of malate to
oxaloacetate, 244
Dehydrogenation of succinate to
fumarate, 244
Dehydrolysinonorleucine, 24
Dehydromerodesmosine, 24
5'-deiodinase, 755
(type I and II), 775
Delayed development
GLUT1 and, 226
Deletion, 546
Dem methylase, 524
Dematin, 480
Dementia
abnormalities that produce, 63
Dénaturation, 58, 527
of DNA, 527
Dénaturation (protein unfolding), 52
Dendritic cells, 808
Dental caries, 140
Deoxy sugars, 142
Deoxycarticosterone (DOC), 750
Deoxycholic acid, 201
6
-deoxyl-L-galactose, 143
Deoxynojirimycin, 316
Deoxypyridinolone, 179
Deoxyribonucleases (DNases), 202, 530
Deoxyribonucleic acid, 521
2
-deoxyribose, 142
Depolarization, 98
Dermatan sulfate (DS), 322
Dermatesparaxis, 589
Desmin, 457
Desmosine, 24, 179
Dexamethasone, 752, 758
DHEA sulfate (DHEAS), 750
DHP receptor, 464
DHPR subunit, 465
25-(OH) DHT, 884
Diabetes
insulin-dependent, 218
mellitus, 495,511,515, 590
cataracts and nephropathy, 32
chronic complications of, 514
diagnosis of, 512
gestational (GDM), 512
high risk groups, 513
management of, 514
miscellaneous causes, 512
specific mutations, 512
type 2 sulfonylureas, 493
mitochondrial disorders, 270
Diabetes insipidus, 2, 933
Diabetes mellitus, 139, 146, 149, 155, 156,
227, 240, 278, 281, 282, 296, 590,
933, 952
citeria for the diagnosis, 513
étiologie classification, 512
type 1, 512
type 2, 228, 512
Diabetic ketoacidosis, 97, 282
Diacylglycérol, 719
Diagnosis of disease, 121
Diagnosis of tissue damage, 126, 128
Diagnostic significance, 949
Dialysis, 37
Diarrhea, 214, 222, 298
Dicarboxylic aminoaciduria, 216
Dichloroacetate, 239, 240
Dicyclohexylcarbodiimide (DCC), 47
Dicyclohexylurea, 47
Diet
calcium, 878
phosphate, 878
protein and, 509
Diet-induced thermogenesis, 224, 263
Dietary fiber, 80, 149, 209
recommended children’s intake, 151
recommended daily intake, 151
role in nutrition, 149
Dietary protein, 331,332
Dietary protein requirement
quality and quantity, 332
Dietary purines, 623
Diethylstilbestrol, 798
Digalactosyldiacylglycerol (DGD), 321
diGeorge’s syndrome, 886
Digestion, 197
intracellular (mucosal) phase, 218
intraluminal phase, 216
Digestion and absorption, 208
Digitalis glycosides, 212
7,8-dihydrobiopterin, 357
Dihydrofolate, 617
Dihydrofolate reductase
inhibition of, 93
Dihydrolipoamide acetyltransferase, 237
Dihydrolipoyl dehydrogenase, 237
Dihydrolipoyl transacetylase, 237, 239
Dihydroorotate, 638, 639
Dihydropyridines, 465
Dihydropyrimidine dehydrogenase
deficiency, 644
Dihydrotachysterol (DHT), 884
Dihydroxy acetone, 133
Dihydroxyacetone phosphate
Isomerization of, 229
1,25-dihydroxy vitamin D, 711
Diisopropylphosphofluoridate (DPF),
se e
DPF
2.4- dinitrofluorobenzene (DNFB; Sanger’s
reagent), 43
Dinitrophenol, 263
2.4- dinitrophenol, 261
2.4- dinitrophenyl amino acid derivatives
(DNP-amino acids), 43
Dioxygenases, 273
Dipeptidases, 215
Dipeptides, 215
Dipeptidylaminopeptidase (DAP), 327
Diphenhydramine, 24
Diphosphatidylglycerol, 405
2,3-diphosphoglycerate, (2,3-DPG),
231,646
Diphtheria, 223, 584
Diphtheria toxin, 585
Dipole effect, 137
Directional flow valve: CYP17, 705
Disaccharides, 144
Discontinuous replication, 548
Disomy, 524
Disorders of glycine catabolism, 348
Displacement loop, 266
Disrupted state, 527
Dissecting aneurysm, 180
Disseminated intravascular coagulation,
184
Dissociation
constant, 104
Dissociation of water, 3
Distinguishing self from nonself, 811
Disturbances in prolactin, 742
Disulfide bonds, 52
Disulfide linkages
assembly of procollagen polypeptides
into triple helix, 589
formation, 588, 589
Disulfiram (tetraethylthiuram disulfide),
378
Diumycin, 316
Divalent metal transporter-1, 676
Divergent evolution, 106
Diverticulitis, 149
Diverticulosis, 149
DMT 1,676, 679
X
DNA, 532
DNA, 521
antibodies, 537
circular and supercoiled, 526
diagnostic clinical, 532
gyrase, 527, 553
ligases, 551, 553
melting temperature, 528
methylase, 556, 604
mutation, 559
